Ajudar Os outros perceber as vantagens da nervocure
Ajudar Os outros perceber as vantagens da nervocure
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Design changes in the second generation device using improved electronic components, circuit boards and digital signaling technology, resulted in reduced weight and increased operational efficiency for people with glioblastoma multiforme, improving the patient experience with TTFields treatment. (Top left, 1st generation Optune; Top Right, 2nd generation Optune; Bottom panels, patients wearing 2nd generation Optune with white and tan arrays).
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TTFields therapy provides clinical versatility that has the potential to help address treatment challenges across a range of solid tumors. To learn more about Tumor Treating Fields therapy and its multifaceted effect on cancer cells, visit tumortreatingfields.usando.
TTFields are low intensity, intermediate frequency alternating electric fields that act upon rapidly dividing glioma and other cancer cells2,3 especially during metaphase, anaphase and telophase of mitotic cell division. When an alternating electric field is generated across a cancer cell, charged molecules within the cell will move back and forth and dipolar molecules will rotate. At sufficiently high frequencies, the motility of such molecules diminishes. Molecules with a high electrical dipole moment such as tubulin dimers and septins are therefore forced to align with the direction of the alternating electric fields (TTFields) under a uniform field distribution, which is generated in cells during metaphase. This disrupts microtubule spindle formation and septin fibres localization during metaphase, leading to mitotic catastrophe, which may culminate in mitotic cell death.
O tratamento da neuropatia facial hereditária é focado em gerenciar ESTES sintomas e sentir melhoramentos a habilidade do vida dos pacientes. Várias abordagens incluem:
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TTFields’ unique mechanism of action underscores key points related to its effective administration and clinical benefit. Unlike chemotherapeutic agents, TTFields are only active while the arrays are affixed to the scalp and the alternating electric fields are generated between the transducer arrays. As a loco-regional and non-invasive targeted therapy, TTFields has the benefit of avoiding systemic adverse events associated with chemotherapy and targeted systemic therapies. The primary treatment-associated adverse event experienced by some patients with TTFields is skin irritation below the arrays, which is predictable and easily manageable in the majority of cases.
Many of the cells, however, will be able to proceed from metaphase to anaphase and telophase. During these phases, the dividing cell assumes an hourglass shape as it begins to split into two distinct daughter cells, causing a non-uniform alternating electric field. This non-uniform field causes polarized cellular components to migrate towards the cleavage furrow of the two daughter cells (an effect called dielectrophoresis) and the dividing cells are unable to divide properly. Overall, the anti-mitotic effect of TTFields may ultimately lead to cell death or to the formation of abnormal dividing cells with an uneven number of chromosomes (Fig. 2).
Pesquise A respeito de a reputaçãeste do profissional do acupuntura previamente de marcar a consulta. Este local de produção e as agulhas devem ser esterilizados de modo a evitar doenças contagiosas.
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About Novocure Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure’s commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma, malignant pleural mesothelioma and pleural mesothelioma.
S. CNS Cancers Franchise. “We are eager to engage with the neuro-oncology community as we strive to extend survival in some of the most aggressive forms of cancer.”